WirkstoffTargetInteraktionen

Wirkstoff-Target-Interaktionen (WTIs) describe the specific interactions between a drug (Wirkstoff) and its molecular target within the body. These interactions are crucial for understanding how a drug exerts its therapeutic effect or causes its side effects. The molecular target can be a protein, such as an enzyme, receptor, or ion channel, that the drug binds to and modulates its activity. The binding affinity and specificity of the drug to its target determine the efficacy and selectivity of the drug. High affinity and specificity are desirable for a therapeutic drug, as they ensure that the drug interacts primarily with its intended target, minimizing off-target effects. Conversely, low affinity or non-specific binding can lead to reduced efficacy and increased toxicity. WTIs are studied using various techniques, including molecular docking, in vitro assays, and in vivo models, to elucidate the mechanisms of drug action and optimize drug design. Understanding WTIs is essential for pharmacology, drug discovery, and the development of safe and effective medications.