Végbélkúpok

Végbélkúpok, commonly known as suppositories in English, are solid dosage forms designed for insertion into the rectum. They are typically medicated and designed to melt or dissolve at body temperature, releasing their active ingredients into the rectal mucosa. This route of administration can be beneficial for several reasons, including bypassing the gastrointestinal tract, which can be useful for patients experiencing nausea, vomiting, or difficulty swallowing. It also allows for absorption into the bloodstream without undergoing first-pass metabolism in the liver, potentially leading to higher bioavailability of certain medications.

The formulation of a suppository involves a base that is solid at room temperature but melts or dissolves at body temperature. Common bases include cocoa butter, polyethylene glycols, and glycerinated gelatin. The active pharmaceutical ingredient is dispersed or dissolved within this base. Végbélkúpok are used to deliver a wide range of medications, including laxatives for constipation, anti-inflammatory drugs for conditions like ulcerative colitis, antiemetics to control nausea, and analgesics for pain relief. The size and shape of suppositories are standardized for ease of use and patient comfort. Their use requires careful consideration of the intended therapeutic effect and the patient's condition.