Vasculotropism

Vasculotropism is a biological phenomenon where cells, tissues, or organs are attracted to or repelled by blood vessels. This process is crucial for various physiological and pathological conditions, influencing tissue growth, repair, and disease progression. Vasculotropism is mediated by a complex interplay of chemical signals, including growth factors, cytokines, and matrix metalloproteinases, which regulate vascular endothelial growth factor (VEGF) expression and vascular permeability. This phenomenon is particularly relevant in cancer, where tumor cells exhibit vasculotropism to form a vascular network that supports their growth and metastasis. Additionally, vasculotropism plays a role in wound healing, where it facilitates the recruitment of endothelial cells to the site of injury. Understanding vasculotropism is essential for developing targeted therapies for diseases characterized by abnormal vascularization, such as cancer and diabetic retinopathy.