UVAtherapieën

UVAtherapieën, also known as ultraviolet A therapy, refers to the medical application of ultraviolet A (UVA) radiation for the treatment of various skin conditions. UVA light is a form of electromagnetic radiation with wavelengths between 320 and 400 nanometers, longer than UVB and UVC radiation. It penetrates deeper into the skin than UVB and is less erythemogenic (less likely to cause redness).

The primary mechanism of UVA therapy involves its interaction with photosensitizing agents. In a process called photochemotherapy, a photosensitizer, commonly a psoralen (a type of medication), is administered orally or applied topically to the skin. This medication makes the skin more sensitive to UVA light. When exposed to UVA radiation, the psoralen becomes activated and intercalates into the DNA of skin cells, inhibiting cell proliferation and reducing inflammation.

UVAtherapieën are most commonly used to treat chronic skin diseases such as psoriasis, eczema (atopic dermatitis), and certain types of cutaneous lymphoma like mycosis fungoides. It can also be employed for vitiligo to stimulate repigmentation. The treatment typically involves sessions in a phototherapy booth where the patient is exposed to controlled doses of UVA light. The frequency and duration of treatments vary depending on the condition being treated and the individual's response.

While generally considered safe when administered under medical supervision, UVA therapy can have side effects. These may include itching, dryness, nausea (if psoralens are taken orally), and an increased risk of skin aging and skin cancer with long-term, cumulative exposure. Therefore, careful monitoring and adherence to treatment protocols are essential.