U13F2

U13F2 is a protein encoded by the U13F2 gene in humans. This gene is part of the U13 family of small nucleolar RNAs (snoRNAs), which are non-coding RNA molecules that play a crucial role in the processing and modification of ribosomal RNA (rRNA). U13F2 is specifically involved in the biogenesis of ribosomes, the cellular machinery responsible for protein synthesis.

The U13F2 snoRNA is found within the nucleolus, a specialized structure within the nucleus of eukaryotic cells. Here, it interacts with various proteins to form a ribonucleoprotein complex, known as a snoRNP. This complex then guides the chemical modifications and specific cleavage events required to mature the precursor rRNA into functional ribosomal subunits. These subunits are essential components of ribosomes, which are composed of both ribosomal RNA and ribosomal proteins.

Dysregulation or mutations in U13F2 have been implicated in certain cellular processes and may be associated with some human diseases, although research in this area is ongoing. Understanding the precise function of U13F2 and its interactions within the nucleolar machinery can provide insights into fundamental cellular processes and potentially contribute to the development of therapeutic strategies for diseases related to ribosome dysfunction.