Tubulusnekrose

Tubulusnekrose, also known as renal tubular necrosis (RTN), is a form of acute kidney injury characterized by the death of tubular cells in the kidneys. These cells form the tubules of the nephrons, which are responsible for filtering waste products from the blood and producing urine. When tubular cells are damaged or die, the kidneys lose their ability to perform these essential functions, leading to a buildup of toxins in the body.

There are two main types of tubulusnekrose: ischemic and nephrotoxic. Ischemic tubulusnekrose occurs when the kidneys do not receive enough blood flow, which can be caused by conditions such as severe dehydration, blood loss, heart failure, or sepsis. Nephrotoxic tubulusnekrose is caused by exposure to toxins that damage the tubular cells. These toxins can include certain medications (such as antibiotics, chemotherapy drugs, and contrast dyes used in medical imaging), heavy metals, or poisons.

Symptoms of tubulusnekrose can vary depending on the severity of the kidney damage and the underlying cause. They may include decreased urine output, swelling in the legs and feet, fatigue, nausea, and confusion. In severe cases, tubulusnekrose can lead to kidney failure, which is a life-threatening condition.

Diagnosis of tubulusnekrose typically involves blood tests to measure kidney function, urine tests to check for abnormalities, and sometimes imaging studies like ultrasound or CT scans. Treatment focuses on addressing the underlying cause of the kidney damage and supporting kidney function. This may involve fluid resuscitation, discontinuing nephrotoxic agents, managing blood pressure, and in severe cases, dialysis to remove waste products from the blood. Prompt diagnosis and treatment are crucial for improving the prognosis and preventing long-term kidney damage.