Tubulointerstitiell

Tubulointerstitiell refers to the part of the kidney comprising the renal tubules and the interstitial tissue that surrounds them. The renal tubules are microscopic structures responsible for reabsorbing essential substances like water, glucose, and amino acids back into the bloodstream, and for secreting waste products into the urine. The interstitial tissue is the connective tissue that fills the spaces between these tubules and the glomeruli, providing structural support and housing blood vessels, lymphatic vessels, and inflammatory cells.

Diseases affecting this region are termed tubulointerstitial diseases. These conditions can arise from various causes, including infections, toxins, medications, autoimmune disorders, and genetic factors. When the tubulointerstitium is damaged, it can impair the kidney's ability to filter waste, regulate electrolytes, and produce urine. Symptoms of tubulointerstitial disease can vary depending on the severity and cause but may include changes in urine output, fatigue, swelling, and electrolyte imbalances. Diagnosis often involves urine tests, blood tests, and sometimes a kidney biopsy to examine the tissue directly. Treatment strategies are tailored to the underlying cause and aim to prevent further kidney damage and manage symptoms.