Transcriptioncoupled
TranscriptionCoupled refers to cellular processes that are tightly linked to transcription and that respond to transcriptional status or transcription-associated damage. In molecular biology, the term is most often used in reference to transcription-coupled nucleotide excision repair (TC-NER), a subpathway that preferentially repairs DNA lesions on the transcribed strand of active genes. This coupling ensures rapid restoration of transcriptional fidelity in genes that are being actively expressed, helping to maintain genome stability.
In bacteria, transcription-coupled repair begins when RNA polymerase stalls at a DNA lesion. A dedicated factor,
In eukaryotes, TC-NER involves recognition of a stalled RNA polymerase II by factors such as CSB and
Biological significance centers on protecting actively expressed genes from mutagenesis and ensuring efficient recovery of transcription