Topicalisers

Topicalisers are a class of substances that are applied to the skin to alter or enhance the effects of other topical agents. They are often used in dermatological or cosmetic applications. The primary function of a topicaliser is to improve the penetration of a drug or active ingredient into the skin, thereby increasing its efficacy. This can be achieved through various mechanisms, such as increasing the permeability of the stratum corneum, the outermost layer of the skin, or by acting as a vehicle for the active compound.

Common examples of topicalisers include penetration enhancers, which can be chemical compounds like dimethyl sulfoxide (DMSO) or oleic acid, or natural substances. Some topicalisers may also possess their own therapeutic benefits, such as anti-inflammatory or moisturizing properties, which can further support the intended treatment. The selection of a topicaliser depends on the specific active ingredient being used, the condition being treated, and the desired outcome. It is important to note that the use of topicalisers should generally be guided by a healthcare professional to ensure safety and optimal results, as they can sometimes increase the risk of adverse reactions to the primary topical agent.