Thr41

Thr41 is a designation used in protein science to identify the threonine residue at position 41 in a protein sequence. This label denotes a specific amino acid within a polypeptide and is commonly found in sequence data, structural models, and literature when discussing a particular residue.

Threonine is a polar, uncharged amino acid that can participate in hydrogen bonding and, in many proteins, serves as a site for post-translational modification. The most common modification at threonine residues is phosphorylation by serine/threonine kinases, though other modifications may occur.

Phosphorylation or other context-dependent roles of Thr41 may influence the protein's activity, interactions with partners, or cellular localization. The functional impact of Thr41 is highly context-dependent and varies with the protein's overall structure and function.

Biochemical and structural studies, including site-directed mutagenesis (for example, T41A or T41V substitutions) and mass spectrometry-based proteomics, are used to assess the role of Thr41 in a given protein.

Conservation of Thr41 across species or within a protein family can indicate functional importance, whereas lack of conservation may suggest a more peripheral role.

In annotation databases such as UniProt and in structural datasets, Thr41 is used as a shorthand to reference this specific residue for researchers examining sequence, structure, or modification data.