Th2dominated

Th2dominated refers to a condition characterized by an overactive T helper 2 (Th2) immune response. T helper cells are a type of lymphocyte that plays a crucial role in the adaptive immune system. They are broadly classified into different subsets, including Th1 and Th2 cells, each with distinct functions. Th1 cells are primarily involved in cell-mediated immunity, combating intracellular pathogens like viruses and bacteria. Th2 cells, on the other hand, are important for humoral immunity, orchestrating responses against extracellular parasites and contributing to allergic reactions.

In a Th2-dominated state, there is an imbalance in the immune system, with Th2 cells being disproportionately active compared to Th1 cells. This can lead to an exaggerated response to allergens and an increased susceptibility to certain types of infections, particularly parasitic ones. The overproduction of Th2 cytokines, such as interleukin-4 (IL-4), IL-5, and IL-13, is a hallmark of this condition. These cytokines promote the production of IgE antibodies, recruit eosinophils, and stimulate mucus production, all of which contribute to the symptoms seen in allergic diseases.

Conditions often associated with a Th2-dominated immune profile include asthma, allergic rhinitis, atopic dermatitis (eczema), and certain parasitic infections. While a Th2 response is essential for defense against specific threats, its dysregulation can lead to chronic inflammation and tissue damage in allergic diseases. Diagnosis and management of Th2-dominated conditions typically involve assessing clinical symptoms, measuring specific IgE levels, and sometimes evaluating cytokine profiles. Treatment strategies aim to dampen the excessive Th2 response through medications like corticosteroids and antihistamines, or by using targeted therapies that block specific Th2 cytokines.