Tensin3

Tensin3 is a protein encoded by the TNS3 gene in humans. It belongs to the tensin family of proteins, which are known for their roles in cell adhesion, migration, and growth. Tensin3, like other tensins, contains a conserved tensin N-terminal domain and a C-terminal phosphotyrosine-binding domain. These structural features suggest its involvement in signaling pathways related to cell structure and communication.

The precise functions of Tensin3 are still under investigation, but research indicates it plays a part in regulating cell spreading and focal adhesion dynamics. Focal adhesions are protein complexes that connect the cell's internal cytoskeleton to the extracellular matrix, acting as crucial sites for cell adhesion and signaling. Tensin3 has been observed to localize to these focal adhesions, influencing their assembly and disassembly. Furthermore, studies suggest Tensin3 may interact with other proteins involved in cytoskeletal organization and signal transduction, potentially mediating responses to mechanical stress or growth factor signaling. Its expression patterns have been noted in various tissues, hinting at a broad role in cellular processes.