TRMT61

TRMT61, also known as TRMT61A, is a protein-coding gene found in humans and other organisms. The gene is responsible for encoding a protein that plays a crucial role in the modification of transfer RNA (tRNA). Specifically, the TRMT61 protein is a component of the TRMT61 complex, which is involved in the methylation of adenine at the N1 position of adenine 37 (m1A37) in tRNA. This modification is essential for the proper function of tRNA, particularly in the decoding of codons during protein synthesis.

The m1A37 modification is conserved across many species and is found in various types of tRNA, including those that carry phenylalanine, tyrosine, and tryptophan. This modification is believed to stabilize the anticodon stem of tRNA and improve its accuracy in recognizing and binding to messenger RNA (mRNA) codons. Without this modification, protein synthesis can be impaired, leading to the production of aberrant proteins or reduced protein levels.

Dysregulation or mutations in TRMT61 have been associated with certain cellular processes and diseases. Research suggests that TRMT61 may be involved in cellular responses to stress and in the regulation of cell growth and proliferation. Further studies are ongoing to fully elucidate the specific functions of TRMT61 and its potential implications in human health and disease. The TRMT61 protein is a member of the methyltransferase family.