TRAF7

TRAF7, also known as TNF receptor associated factor 7, is a protein encoded by the TRAF7 gene. It belongs to the TNF receptor-associated factor family, which are intracellular signaling molecules involved in immune responses and cell survival. TRAF7 plays a crucial role in various cellular processes, including signal transduction, gene regulation, and protein ubiquitination.

The protein contains several conserved domains, including a RING finger domain and a coiled-coil domain, which are essential for its function. TRAF7 interacts with a wide range of signaling molecules, including TNF receptors, toll-like receptors, and various other protein complexes. These interactions allow TRAF7 to integrate signals from different pathways, contributing to the complex regulation of cellular events.

Dysregulation of TRAF7 has been implicated in several human diseases, including cancer and neurodevelopmental disorders. In cancer, TRAF7 can act as either an oncogene or a tumor suppressor, depending on the cellular context. Its involvement in regulating cell proliferation, apoptosis, and genomic stability makes it a potential target for cancer therapies. Furthermore, mutations in TRAF7 have been linked to certain intellectual disabilities and developmental abnormalities, highlighting its importance in normal brain development. Research continues to explore the intricate mechanisms by which TRAF7 influences cellular function and its potential therapeutic applications.