TP63related

TP63-related refers to a group of proteins that are closely related to the tumor protein p63 (TP63). TP63 is a transcription factor that plays a crucial role in the development and maintenance of epithelial tissues, particularly in the skin, esophagus, and anus. The TP63-related proteins include TP63 itself, as well as its isoforms, deltaNp63 and deltaNp73, which are generated through alternative splicing.

TP63-related proteins are involved in various cellular processes, including cell proliferation, differentiation, and apoptosis. They regulate the expression of genes that are essential for maintaining the integrity and function of epithelial tissues. Mutations in TP63 and its related proteins have been linked to several human diseases, including cancer and genetic disorders.

TP63-related proteins are also of interest in the field of regenerative medicine, as they have the potential to promote tissue repair and regeneration. Research is ongoing to understand the mechanisms by which these proteins regulate cellular processes and to develop therapeutic strategies that target them for the treatment of diseases.