TNFreseptorin

TNFreseptorin is a transmembrane protein that plays a crucial role in the immune system. It belongs to the tumor necrosis factor receptor superfamily, a group of cell surface receptors involved in a wide range of biological processes including cell survival, proliferation, differentiation, and apoptosis. TNFreseptorin is characterized by its extracellular cysteine-rich domains and intracellular death domain, which is essential for initiating signaling pathways.

This receptor is expressed on various immune cells, such as T lymphocytes, B lymphocytes, and macrophages. Upon binding to its cognate ligand, tumor necrosis factor (TNF), TNFreseptorin triggers downstream signaling cascades. These cascades can lead to the activation of transcription factors like NF-κB, which in turn regulate the expression of genes involved in inflammation, immunity, and cell death. The specific outcome of TNFreseptorin activation can depend on the cell type and the presence of co-receptors. Dysregulation of TNFreseptorin signaling has been implicated in various inflammatory and autoimmune diseases, making it a target of therapeutic interest. Research into TNFreseptorin continues to unravel its complex roles in maintaining immune homeostasis and its contribution to disease pathogenesis.