TNFS3

TNFS3, also known as tumor necrosis factor superfamily member 3, is a protein that in humans is encoded by the TNFSF3 gene. This gene is located on chromosome 17q21.3. TNFS3 is a member of the tumor necrosis factor superfamily, which includes various cytokines and receptors involved in immune and inflammatory responses.

The TNFSF3 gene is approximately 10.5 kilobases in length and consists of 11 exons. It is expressed in a variety of tissues, including the brain, heart, and immune cells. The protein encoded by this gene is a type II transmembrane protein that belongs to the tumor necrosis factor superfamily. It is primarily expressed on the surface of immune cells, where it plays a role in cell-cell interactions and immune regulation.

TNFS3 is involved in the regulation of immune responses and inflammation. It can bind to various receptors, including TNFRSF1A (also known as CD120a), which is a member of the TNF receptor superfamily. The interaction between TNFS3 and its receptors can lead to the activation of signaling pathways that regulate immune cell function and inflammation.

Mutations in the TNFSF3 gene have been associated with various immune-related disorders, including autoimmune diseases and inflammatory conditions. However, the specific role of TNFS3 in these disorders is not yet fully understood. Further research is needed to elucidate the precise functions of TNFS3 and its potential as a therapeutic target for immune-related diseases.