TMEM8C

TMEM8C, short for transmembrane protein 8C, is a vertebrate protein-coding gene that encodes a member of the transmembrane protein 8 family. The predicted TMEM8C protein contains multiple transmembrane helices and is presumed to be associated with cellular membranes.

The TMEM8 gene family comprises several paralogs in vertebrates, and TMEM8C has orthologs across diverse species, indicating evolutionary conservation of this membrane-associated protein. Detailed functional studies are limited, and the precise role of TMEM8C remains to be established.

Expression analyses show TMEM8C transcription in multiple tissues, with patterns that can vary by species. The protein is expected to reside in membranes, consistent with possible involvement in transport, signaling, or other membrane-related processes, but specific cellular functions have not been definitively determined.

In humans and other mammals, there are no widely recognized disease associations linked to TMEM8C, and it is not a major focal point in clinical research. Current knowledge comes primarily from public gene and protein databases that provide sequence information, predicted structural features, and evolutionary relationships.

See also: TMEM8 family. For further details, researchers can consult resources such as NCBI Gene and UniProt to access sequence data, expression profiles, and comparative genomics information.