THIQ
THIQ, short for 1,2,3,4-tetrahydroisoquinoline, is a bicyclic organic compound that combines a benzene ring fused to a saturated six-member ring containing a secondary amine. It is the hydrogenated form of isoquinoline and serves as a versatile scaffold in organic synthesis and medicinal chemistry. The nitrogen atom is part of a secondary amine, making THIQ and its derivatives moderately basic and capable of forming common amine salts.
Synthesis: THIQs are prepared by several routes. A widely used method is catalytic hydrogenation of isoquinoline
Occurrence and significance: The tetrahydroisoquinoline motif occurs in numerous natural products and commercially important compounds. It
Applications: In medicinal chemistry, THIQs are used as scaffolds for the development of central nervous system