TFPISpiegel

TFPISpiegel is a protein that plays a crucial role in the regulation of the complement system, a part of the innate immune system. It is encoded by the TFPI gene in humans. The complement system is a cascade of proteins that work together to identify and eliminate pathogens, damaged cells, and other harmful substances.

TFPISpiegel is a member of the Kunitz-type serine protease inhibitor (Kunitz) family. It inhibits two key serine proteases in the complement system: tissue factor pathway inhibitor (TFPI) and factor Xa. TFPISpiegel binds to these proteases, preventing them from cleaving their substrates and thereby regulating the complement cascade.

The TFPI gene is located on chromosome 17q23.3. Mutations in this gene have been associated with an increased risk of developing age-related macular degeneration (AMD), a leading cause of blindness in the elderly. TFPISpiegel is also involved in the regulation of other biological processes, including angiogenesis and inflammation.

Research on TFPISpiegel is ongoing, with studies exploring its potential as a therapeutic target for various diseases. Its role in the complement system and its involvement in AMD highlight its significance in both basic and clinical research.