TEMPOoxidáció
TEMPO oxidation refers to a class of chemical reactions that utilize the stable nitroxyl radical TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl) as a catalyst to oxidize alcohols to carbonyl compounds. This method is particularly valuable for the selective oxidation of primary alcohols to aldehydes and secondary alcohols to ketones, often under mild conditions.
The mechanism typically involves the oxidation of TEMPO to the corresponding oxoammonium cation, which then acts
TEMPO-mediated oxidations offer several advantages. They are known for their high selectivity, tolerating a wide range