TAt1

TAt1 is a designation used in genome annotation to refer to a conserved, predicted membrane-associated protein found in a range of organisms. In many databases, TAt1 entries describe proteins typically in the 180–220 amino acid range and predicted to contain multiple transmembrane helices, consistent with roles in membrane-associated processes. The acronym TAt1 has been used differently across species, and the exact naming may vary.

Discovery and nomenclature: The term arose from comparative genomics studies that identified a family of homologous proteins with a shared predicted topology but little characterized function.

Structure and localization: Predicted topology includes four to six transmembrane segments; no definitive catalytic domain has been identified. Subcellular localization is predicted to include the plasma membrane and internal membranes such as the endomembrane system.

Function and experiments: Functional evidence remains limited. Some genetic or RNA interference studies report mild or conditional phenotypes, while others show no obvious effects. Biochemical data are sparse, but TAt1 is hypothesized to participate in membrane trafficking, ion homeostasis, or assembly of multiprotein membrane complexes.

Evolution and significance: TAt1 homologs are identified across diverse taxa, with stronger conservation in certain lineages suggesting an ancient origin and lineage-specific diversification. No disease associations or industrial applications are established, and TAt1 remains an active area of basic research.