TAp73

TAp73 is a protein encoded by the TP73 gene. It is a member of the p73 family of transcription factors, which are structurally and functionally related to the well-known tumor suppressor p53. TAp73 is an isoform of the p73 protein, distinguished by the presence of a transactivation domain. This transactivation domain allows TAp73 to activate the transcription of target genes.

TAp73 plays a role in various cellular processes, including cell cycle arrest, apoptosis, and differentiation. It can induce programmed cell death in response to DNA damage or other cellular stresses, similar to p53. However, TAp73's function can be context-dependent and can sometimes act as an oncogene or a tumor suppressor depending on the cellular environment and the specific isoform involved.

Research suggests that TAp73 is involved in neuronal development and the maintenance of genomic stability. Dysregulation of TAp73 has been implicated in the development and progression of several types of cancer. The TP73 gene can produce multiple isoforms through alternative splicing and promoter usage, leading to proteins with different functional properties. TAp73 is one of the full-length isoforms with a transactivation domain.