Slitrks
SLITRKs, or neurotrophic tyrosine kinase receptor-interacting proteins, are a family of transmembrane proteins encoded by the SLITRK genes in humans. There are six members in this family: SLITRK1, SLITRK2, SLITRK3, SLITRK4, SLITRK5, and SLITRK6. These proteins are characterized by an extracellular region containing leucine-rich repeats and immunoglobulin-like domains, a transmembrane domain, and an intracellular domain that interacts with various signaling molecules.
SLITRKs are widely expressed in the developing and adult nervous system, playing crucial roles in neuronal
Dysregulation of SLITRK gene expression or mutations have been associated with several neurological and psychiatric disorders.