Sincitios
Sincitios are multinucleated cells that arise when two or more cells fuse to form a single cytoplasmic mass containing multiple nuclei. They are also referred to as syncytia, and the term is used in both human biology and pathology.
Sincitios form during normal development and in certain tissues. In skeletal muscle, myoblasts fuse to create
Formation is driven by fusogenic membrane proteins and signaling pathways that promote membrane merge and cytoplasmic
Physiological roles include increased cytoplasmic volume and coordinated cellular activity in tissues like muscle, where the
Pathologically, viruses can induce syncytium formation through envelope glycoproteins that mediate cell fusion, contributing to tissue
Observation typically relies on light microscopy, where nuclei are dispersed within a shared cytoplasm, or electron