Simethicone

Simethicone is an over-the-counter anti-foaming agent used to relieve gas-related discomfort such as bloating, pressure, fullness, and flatulence. It works by decreasing surface tension of gas bubbles in the stomach and intestines, causing scattered small bubbles to combine into larger bubbles that are easier to pass. Because simethicone is not absorbed from the gastrointestinal tract, its action is local and there are no meaningful systemic effects.

Indications and forms: It is used to relieve symptoms of excess gas in adults and in many pediatric formulations. Available forms include oral suspensions, chewable tablets, soft-gel capsules, and products combined with antacids. For infants and children, dosing is lower and must follow the product’s label or a clinician’s guidance.

Administration: Dosing is defined on product labeling. In general, doses are given after meals and at bedtime as needed, with a maximum daily dose specified on the label. Do not exceed recommended dosing or use with other products containing simethicone unless advised.

Safety: Simethicone is typically well tolerated. Adverse effects are rare and may include mild diarrhea or an allergic reaction, but systemic interactions are unlikely due to lack of absorption. It has no clinically significant drug interactions.

Pregnancy and lactation: Considered safe when used as directed; consult a healthcare provider if there are concerns or if there are concurrent conditions. It can be used in infants under pediatrician guidance, including for colic in some products, though evidence for efficacy in colic is limited.

Pharmacokinetics: After ingestion, simethicone is not absorbed and is excreted unchanged in stool.