SigmaE
SigmaE, also known as sigma factor E or RpoE, is an extracytoplasmic function (ECF) sigma factor of bacterial RNA polymerase that directs transcription in response to envelope and periplasmic stress, particularly in Gram-negative bacteria such as Escherichia coli. It regulates a group of genes that help restore cell envelope integrity and protein folding in the periplasm.
Under normal conditions, sigmaE is kept inactive by its anti-sigma factor RseA, an inner membrane protein. When
The sigmaE regulon includes periplasmic chaperones and proteases (for example, DegP/HtrA, FkpA, Skp), components involved in
SigmaE is essential for managing extracytoplasmic stress in many bacteria and contributes to pathogenicity in some