SerumMethylmalonsäure
SerumMethylmalonsäure refers to the concentration of methylmalonic acid (MMA) in the blood serum. Methylmalonic acid is a small molecule produced during the metabolism of certain amino acids, specifically valine, isoleucine, threonine, and methionine. It is also a byproduct of the breakdown of odd-chain fatty acids. In the body, MMA is normally converted into succinyl-CoA, an intermediate in the citric acid cycle, with the help of vitamin B12 (cobalamin) as a cofactor.
Elevated levels of serum methylmalonic acid are a sensitive indicator of vitamin B12 deficiency. When vitamin
Besides vitamin B12 deficiency, increased serum MMA levels can also be observed in other conditions, although