Sema4Sema7

Sema4Sema7 refers to a specific pair of semaphorin proteins, semaphorin-4D (SEMA4D) and semaphorin-7A (SEMA7A). Semaphorins are a large family of transmembrane proteins known for their role as guidance cues in the nervous system. They are involved in axon guidance, cell migration, and tissue patterning during development and in adult physiology.

SEMA4D, also known as CD100, is expressed on various cell types, including immune cells and neurons. It interacts with its known receptor, plexin-B1, and can also bind to other plexins, influencing cellular responses. SEMA4D has been implicated in immune cell trafficking, B cell activation, and T cell responses. In the nervous system, it has been shown to play roles in neuronal development and plasticity.

SEMA7A, also known as semaphorin-7A or CD108, is another member of the semaphorin family. It can be expressed in a soluble or membrane-bound form. SEMA7A has been identified to interact with plexins and can also bind to integrins, particularly beta-1 integrins, which allows it to mediate cell adhesion and migration. SEMA7A is involved in a variety of processes, including immune cell function, bone remodeling, and wound healing. It has also been studied for its potential role in neurological conditions.

The interplay between SEMA4D and SEMA7A, either through independent signaling pathways or potential cross-talk, is an area of ongoing research. Understanding their distinct and overlapping functions can provide insights into developmental processes and the pathogenesis of various diseases.