STAT3driven
STAT3driven refers to biological processes or diseases that are primarily influenced or driven by the activity of the Signal Transducer and Activator of Transcription 3 (STAT3) protein. STAT3 is a transcription factor that plays a crucial role in cellular signaling pathways, responding to a variety of extracellular stimuli such as cytokines and growth factors. Upon activation, STAT3 translocates to the nucleus where it regulates the expression of genes involved in cell survival, proliferation, differentiation, immune response, and angiogenesis.
In many cancers, STAT3 becomes constitutively activated, meaning it is always "on" regardless of normal signaling
Beyond cancer, STAT3 plays roles in other physiological and pathological conditions. It is involved in inflammatory