SOS1GRB2

SOS1GRB2 is a gene that encodes a protein involved in cellular signaling. This protein is a guanine nucleotide exchange factor (GEF) for the Ras family of small GTPases. GEFs play a crucial role in cell growth, differentiation, and survival by activating Ras proteins. Specifically, SOS1GRB2 is known to interact with the Son of Sevenless homolog 1 (SOS1) protein, which is also a GEF. The interaction between SOS1 and GRB2 (Growth Factor Receptor-Bound Protein 2) is a key event in the activation of the Ras-MAPK signaling pathway. This pathway is frequently dysregulated in various cancers. The GRB2 protein itself acts as an adaptor protein, linking activated receptor tyrosine kinases to downstream signaling molecules, including SOS1. Therefore, the SOS1GRB2 complex facilitates the transfer of a GTP molecule to Ras, initiating a cascade of events that ultimately influence cellular behavior. Research into SOS1GRB2 and its role in signaling pathways is ongoing, with a focus on understanding its contribution to normal cellular processes and its potential involvement in disease pathogenesis. Targeting this pathway is an area of interest for developing therapeutic strategies for cancer and other diseases where Ras signaling is aberrant.