SLC41

SLC41 refers to a family of solute carrier proteins, specifically the sodium-calcium exchangers. These proteins are primarily involved in the transport of ions across cell membranes. The SLC41 family is characterized by its members' ability to facilitate the movement of sodium ions (Na+) and calcium ions (Ca2+) across the plasma membrane. This transport is crucial for maintaining cellular homeostasis, particularly in regulating intracellular calcium concentrations.

There are three known members within the SLC41 family: SLC41A1, SLC41A2, and SLC41A3. These proteins are found in various tissues throughout the body and play roles in different physiological processes. For instance, SLC41A1 has been implicated in neuronal excitability and magnesium transport, suggesting a broader ion transport function beyond just sodium and calcium. The precise mechanisms and substrates for SLC41A2 and SLC41A3 are still under active investigation.

Dysfunction of SLC41 family members has been associated with certain human diseases. For example, mutations in SLC41A1 have been linked to neurological disorders and kidney conditions. Research into the SLC41 family is ongoing to further elucidate their specific functions, molecular mechanisms, and potential therapeutic applications. Understanding these transporters is vital for comprehending cellular ion balance and its impact on health.