SGLT1transporteri
Sodium-glucose cotransporter 1, commonly abbreviated as SGLT1, is a protein primarily found in the intestinal brush border and the renal proximal tubules. Its main function is the reabsorption of glucose from the lumen of the intestine and kidney back into the bloodstream. This process is coupled with the movement of sodium ions, which provides the energy gradient for glucose transport. SGLT1 is a high-affinity, low-capacity transporter, meaning it is efficient at reabsorbing glucose even when its concentration is low, but it can become saturated at high concentrations.
In the intestine, SGLT1 plays a crucial role in absorbing dietary glucose and other monosaccharides from digested
Dysfunction or inhibition of SGLT1 can lead to various physiological consequences. For instance, mutations in the