SEMG2

SEMG2, also known as Semaphorin-7A, is a protein-coding gene. It belongs to the semaphorin family, which are secreted or membrane-bound proteins characterized by a conserved semaphorin domain. These proteins are involved in a wide range of biological processes, including axon guidance, cell migration, immune cell function, and tissue development.

The SEMG2 gene encodes a transmembrane protein that plays a significant role in the immune system. It is expressed on various immune cells, including T cells and macrophages, and also on some non-immune cells like neurons and osteoclasts. Semaphorin-7A is known to interact with specific receptors, such as plexins and integrins, to mediate its cellular functions.

In the context of immunity, SEMG2 has been implicated in regulating T cell activation, differentiation, and migration. It can influence the balance between pro-inflammatory and anti-inflammatory responses. Furthermore, Semaphorin-7A has been observed to play a role in bone remodeling and osteoclast differentiation, as well as in the development and function of the nervous system. Dysregulation of SEMG2 has been associated with various diseases, including autoimmune disorders and certain types of cancer, suggesting its importance in maintaining cellular homeostasis and immune surveillance. Research into the precise mechanisms of SEMG2 action and its therapeutic potential is ongoing.