SEC14
Sec14 is a cytosolic phospholipid transfer protein in the budding yeast Saccharomyces cerevisiae and the founding member of the Sec14-like protein superfamily. It is essential for proper Golgi function and the secretory pathway, coordinating lipid metabolism with vesicle formation and cargo sorting.
Functionally, Sec14 binds and transfers specific phospholipids, notably phosphatidylinositol and phosphatidylcholine, between membrane surfaces. In the
Structurally, Sec14 contains a hydrophobic lipid-binding pocket that accommodates PI and PC. The protein cycles between
Genetically, Sec14 is essential for viability in S. cerevisiae; mutants with defective Sec14 function exhibit severe
Broader context notes that Sec14-like proteins are conserved across eukaryotes and are classified as phosphatidylinositol transfer