SCFSkp2

SCFSkp2 is a human protein that is encoded by the FBXO4 gene located on the X chromosome. This gene is a member of the F-box gene family, which encodes proteins that are involved in the ubiquitin-proteasome pathway. The product of the FBXO4 gene, SCFSkp2, is a component of the SCF (Skp1-Cullin-F-box) complex, which plays a crucial role in protein degradation.

SCFSkp2 is a substrate specificity component of the SCF complex, and it has been shown to specifically target certain proteins for degradation. In particular, SCFSkp2 has been implicated in the regulation of cell cycle progression by targeting proteins involved in the cell cycle for degradation. Abnormal expression of SCFSkp2 has been linked to various diseases, including cancer.

Research has shown that SCFSkp2 has a complex and dynamic interaction with other proteins that regulate the cell cycle. For example, SCFSkp2 has been shown to interact with cyclin-dependent kinases (CDKs), which are essential for cell cycle progression. These interactions are crucial for regulating the timing of cell cycle progression and ensuring proper cellular division.

The SCFSkp2 protein has also been shown to have a role in cancer, particularly in the development and progression of certain types of cancer. Overexpression of SCFSkp2 has been observed in various cancer types, leading to uncontrolled cell growth and tumor development. Further research is needed to fully understand the complex role of SCFSkp2 in cancer development and progression.