FBXO4

FBXO4, also known as F-box protein 4, is a protein encoded by the FBXO4 gene. It is a component of the SCF complex (Skp1-cullin-F-box protein), which is a type of ubiquitin ligase. Ubiquitin ligases are enzymes that play a crucial role in protein degradation by tagging target proteins with ubiquitin molecules, marking them for destruction by the proteasome.

The F-box protein family is characterized by the presence of an F-box motif, which is essential for binding to Skp1, another component of the SCF complex. FBXO4 specifically interacts with Skp1 through its F-box domain. The other component of the SCF complex that FBXO4 interacts with is cullin protein, which helps to assemble the E3 ubiquitin ligase.

FBXO4 is believed to be involved in regulating various cellular processes, including cell cycle progression, DNA repair, and signal transduction. Its specific substrates and the precise mechanisms by which it mediates protein degradation are areas of ongoing research. Dysregulation of FBXO4 has been implicated in certain diseases, including some types of cancer, suggesting its potential role as a therapeutic target. Further investigation into the functions and interactions of FBXO4 is vital for understanding its contribution to normal cellular physiology and disease pathogenesis.