Reseptortetthet
Reseptortetthet refers to the concentration of cellular receptors within a given area of biological tissue, typically expressed as the number of receptors per unit of membrane surface or per unit mass of tissue. It is a fundamental concept in pharmacology, neuroscience, and cell biology, because the functional response of a cell to a ligand often depends not only on the affinity of the receptor but also on how many receptors are available to bind the ligand.
The measurement of reseptortetthet can be performed by various techniques. Saturation binding assays using radioligands provide
Receptor density influences drug potency and efficacy. A high reseptortetthet may lead to greater sensitivity to
In neuroscience, reseptortetthet of neurotransmitter receptors such as NMDA, AMPA, or dopamine D2 receptors is used
Overall, reseptortetthet is a critical variable that informs drug development, diagnostic imaging, and the understanding of