Rap1GAPs
Rap1GAPs are a family of GTPase-activating proteins (GAPs) that specifically regulate the activity of Rap1 GTPases. Rap1 is a member of the Ras superfamily of small GTPases, which act as molecular switches in various cellular signaling pathways. GAPs are proteins that enhance the intrinsic GTPase activity of small GTPases, thereby promoting their conversion from the active GTP-bound state to the inactive GDP-bound state.
The primary function of Rap1GAPs is to inactivate Rap1. By accelerating the hydrolysis of GTP to GDP
There are several known Rap1GAP proteins in mammals, including Rap1GAP1, Rap1GAP2, and Rap1GAP3. These proteins share
Dysregulation of Rap1GAP activity or expression has been implicated in various diseases, including cancer and inflammatory