Rab3Abinding
Rab3Abinding refers to the molecular interactions between Rab3A, a small GTPase of the Rab family, and its binding partners. Rab3A cycles between a GDP-bound inactive state and a GTP-bound active state; recruitment of effector proteins to Rab3A depends on the GTP-bound conformation and regulates stages of the vesicle life cycle in neurons and other secretory cells.
On synaptic vesicles, Rab3A in its active form engages downstream effectors that influence neurotransmitter release. Classic
In addition to these effectors, Rab3Abinding also encompasses Rab3A-binding proteins such as RAB3BP (Rab3A-binding protein). Such
Rab3A binding is a key component of the broader Rab GTPase cycle that coordinates vesicle trafficking in