RAB3BP

RAB3BP (RAB3B, member of the RAB3 GTPase family, binding protein) is a protein encoded by the RAB3BP gene in humans. It is part of the larger RAB family of small GTPases, which are involved in intracellular vesicle trafficking and membrane dynamics. RAB3BP is identified as a putative effector or regulatory partner for RAB3B, a member that plays a significant role in neurotransmitter release and synaptic vesicle exocytosis.

The RAB3BP protein is thought to function as a binding partner that influences RAB3B activity, thereby modulating processes such as vesicle docking and fusion within neuronal and secretory cells. Its interaction with RAB3B suggests a role in the regulation of neurotransmitter release and possibly in other secretory pathways.

Research on RAB3BP is ongoing to better understand its precise biological functions and mechanisms. Its expression patterns are observed in various tissues, particularly those involved in secretion and neurotransmission. Mutations or dysregulation of RAB3BP have potential implications for neurological and secretory disorders, although specific disease associations are still under investigation.

Overall, RAB3BP is considered an essential component in the regulation of vesicle trafficking mediated by RAB3B, contributing to cellular processes fundamental for neuronal communication and secretion. Its study may provide insights into neurobiology and related pathological conditions.