RUVBL1RUVBL2

RUVBL1RUVBL2 is a protein complex that plays a crucial role in the regulation of gene expression and DNA repair in eukaryotic cells. The complex is composed of two subunits, RUVBL1 and RUVBL2, which are both members of the RuvB-like (RBL) family of proteins. These proteins are conserved across various eukaryotic species, indicating their essential functions in cellular processes.

RUVBL1RUVBL2 is involved in the regulation of transcription by interacting with the Mediator complex, a large protein complex that integrates signals from various transcription factors and regulates the assembly of the preinitiation complex. This interaction is essential for the proper functioning of the Mediator complex and the initiation of transcription.

In addition to its role in transcription, RUVBL1RUVBL2 is also implicated in DNA repair. It has been shown to interact with the DNA damage response protein p53, suggesting a potential role in the regulation of DNA repair pathways. However, the exact mechanisms by which RUVBL1RUVBL2 regulates DNA repair remain to be fully elucidated.

The structure of the RUVBL1RUVBL2 complex has been determined by X-ray crystallography, revealing a unique fold that is characteristic of the RBL family of proteins. The complex forms a heterodimer, with RUVBL1 and RUVBL2 interacting through a conserved interface. This interaction is mediated by a series of hydrophobic residues and is essential for the stability and function of the complex.

In summary, RUVBL1RUVBL2 is a protein complex with essential roles in the regulation of gene expression and DNA repair. Its interaction with the Mediator complex and DNA damage response proteins highlights its importance in cellular processes. Further research is needed to fully understand the mechanisms by which RUVBL1RUVBL2 regulates these processes.