RBM39

RBM39, also known as Ring Finger Protein 39, is a protein that in humans is encoded by the RBM39 gene. This gene is located on chromosome 19q13.3. RBM39 is a member of the RNA-binding motif (RBM) family of proteins, which are involved in various cellular processes, including RNA splicing, transport, and stability.

The RBM39 protein contains multiple RNA-binding domains, which allow it to interact with different types of RNA molecules. These interactions are crucial for its role in regulating gene expression. RBM39 has been shown to bind to specific sequences in the 3' untranslated regions (3' UTRs) of target mRNAs, thereby modulating their stability and translation.

Mutations in the RBM39 gene have been associated with several genetic disorders, including intellectual disability, autism spectrum disorder, and epilepsy. These mutations can disrupt the normal function of the RBM39 protein, leading to abnormal gene expression patterns and contributing to the development of these conditions.

Research on RBM39 is ongoing, with studies aimed at understanding its precise mechanisms of action and identifying potential therapeutic targets for related disorders. The protein's role in RNA regulation makes it a promising candidate for further investigation in the context of RNA-based therapies.