RBL2B

RBL2B, also known as retinoblastoma-like protein 2B, is a protein encoded by the RBL2 gene. It belongs to the retinoblastoma protein family, which plays a crucial role in regulating cell cycle progression. RBL2B functions as a transcription repressor, meaning it can bind to DNA and inhibit the transcription of genes that promote cell division. This regulatory function is essential for preventing uncontrolled cell growth, a hallmark of cancer.

The protein is involved in maintaining genomic stability and is implicated in differentiation processes in various cell types. RBL2B interacts with other proteins, including transcription factors and components of the cell cycle machinery, to exert its effects. Dysregulation of RBL2B has been observed in several types of cancer, suggesting its potential as a tumor suppressor. Research into RBL2B continues to explore its precise mechanisms of action and its therapeutic implications.