QTRAPs

QTRAPs, or Quadruple-Residue Transiently Associated Proteins, are a class of proteins that have been identified through yeast two-hybrid screening. This technique is used to detect protein-protein interactions. The term "QTRAP" refers to proteins that show interactions with other proteins in a manner that is not constant but rather transient and involves a specific motif containing four amino acid residues. These interactions are thought to play roles in various cellular processes, including signal transduction, gene regulation, and protein complex assembly. The identification of QTRAPs has contributed to a better understanding of the dynamic nature of protein networks within cells. Research into QTRAPs is ongoing to further elucidate their specific functions and the mechanisms by which they mediate their transient associations. Understanding these interactions is crucial for comprehending cellular complexity and for potential therapeutic interventions targeting specific protein pathways. The discovery of QTRAPs highlights the importance of transient protein interactions in biological systems, which may not always be captured by methods detecting stable complexes.