QKI6

QKI6 is an isoform of the QKI gene, a member of the STAR family of RNA-binding proteins. Like other QKI family members, QKI6 is produced by alternative splicing and contains a conserved RNA-binding KH domain that supports sequence-specific interaction with RNA. The different C-terminal regions among QKI isoforms influence subcellular localization, and QKI6 is primarily associated with the cytoplasm.

In terms of function, QKI6 participates in post-transcriptional regulation of target mRNAs. It binds to RNA elements recognized by the Quaking response element (QRE) and can influence processes such as mRNA stability, localization, splicing, and translation. Through these actions, QKI6 contributes to the control of gene expression programs in which cytoplasmic RNA fate is important, including those related to cytoskeletal dynamics and membrane protein production.

Expression of QKI6 is detected in neural and glial tissues, with higher levels observed during development and in cells involved in myelination, such as oligodendrocytes. Its activity is often discussed in the context of other QKI isoforms, which together regulate networks of RNA transcripts essential for neural differentiation and maturation.

Clinical and research relevance notes that dysregulation of QKI proteins, including QKI6, can impact myelination and neural development in model systems. Studies of QKI isoforms contribute to understanding how post-transcriptional control shapes glial biology and neurological function. QKI6 remains a focus in investigations of RNA binding protein–mediated regulation within the nervous system.