Pseudoallergische

Pseudoallergic is a term used to describe reactions that mimic allergic responses but do not involve the typical immunological mechanisms of allergy. Unlike true allergies, which are mediated by IgE antibodies and the release of histamine, pseudoallergic reactions are triggered by direct activation of mast cells or other inflammatory pathways without this specific immune system involvement. These reactions can be caused by a variety of substances, including certain foods, food additives, medications, and environmental factors. Symptoms can range from mild skin rashes, itching, and hives to more severe reactions like gastrointestinal upset, breathing difficulties, and angioedema. Diagnosis can be challenging as it relies on a careful medical history, exclusion of true allergies, and sometimes challenge tests under medical supervision. Treatment typically involves avoiding the suspected trigger substance and managing symptoms with antihistamines or other appropriate medications. Understanding the difference between true allergies and pseudoallergic reactions is crucial for accurate diagnosis and effective management.