ProPTH
proPTH refers to the precursor form of parathyroid hormone (PTH), typically understood as the prohormone that gives rise to mature PTH. In humans, the PTH gene encodes a preprohormone that includes an N-terminal signal peptide, a prosegment (often described as proPTH), and the C-terminal PTH sequence. This arrangement directs the molecule through the secretory pathway and primes it for processing.
Biogenesis and processing occur in parathyroid chief cells and other neuroendocrine contexts. The signal peptide directs
Function and mechanism are mediated by the PTH1 receptor, primarily in bone and kidney. PTH raises serum
Clinical relevance centers on measuring parathyroid function, where intact PTH is routinely assessed. ProPTH serves as