Polycombregulated
Polycomb-regulated describes genes or genomic regions whose transcription is controlled by Polycomb group (PcG) protein complexes, notably PRC1 and PRC2. These complexes mediate heritable transcriptional repression through histone modifications, including PRC2-catalyzed trimethylation of histone H3 at lysine 27 (H3K27me3) and PRC1-mediated monoubiquitination of histone H2A at lysine 119 (H2AK119ub1). The combined activities promote a repressive chromatin state and reduced accessibility of the transcriptional machinery.
Many Polycomb-regulated loci are developmentally regulated. In embryonic stem cells, a subset of PcG targets displays
Recruitment and maintenance of Polycomb repression are complex and context-dependent. PcG targeting involves multiple components and
Polycomb-regulated genes control key developmental decisions and stem cell identities. Dysregulation of PcG function, such as