PhosphoproteomicsDB

PhosphoproteomicsDB is a publicly accessible database that consolidates quantitative and qualitative data from mass spectrometry-based phosphoproteomics studies. It focuses on site-specific phosphorylation information across proteins, enabling researchers to explore how phosphorylation at particular residues varies across different biological contexts.

Data in PhosphoproteomicsDB include protein identifiers (with cross-references to UniProt), the phosphorylated residue and position, peptide evidence, site localization scores, and the experimental context (species, tissue or cell type, treatment conditions). For many entries, quantitative measurements such as reporter ion intensities or fold changes are provided across multiple samples or experiments, allowing comparisons of phosphorylation dynamics.

Data sources are large-scale phosphoproteomics studies as well as curated annotations; sites are mapped to stable protein sequences and linked to external resources such as PhosphoSitePlus and UniProt to facilitate interpretation.

Access is provided through a web interface that supports searching by protein, gene, phosphorylation site, or sample metadata. Users can browse protein pages, view site-centric information and supporting evidence, and download selected data sets for offline analysis. The resource aims to enable meta-analyses of phosphorylation dynamics, cross-study comparisons, and functional interpretation of signaling networks.

PhosphoproteomicsDB is maintained by researchers in proteomics and bioinformatics and is widely used by the scientific community as a reference resource in phosphoproteomics studies.

See also: PhosphoSitePlus, UniProt, ProteomicsDB.